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Importantly, these receptors have been observed to have been activated by a variety of endogenous opioids at a concentration much like that noticed for activation and signaling of classical opiate receptors. Consequently, these receptors were uncovered to possess scavenging activity, binding to and lowering endogenous amounts of opiates accessible

Importantly, these receptors were located to have been activated by an array of endogenous opioids in a focus comparable to that observed for activation and signaling of classical opiate receptors. Consequently, these receptors ended up found to get scavenging action, binding to and lowering endogenous levels of opiates accessible for binding to op